Quantitative Radioautography of Sugar Transport in Intestinal Biopsies from Normal Humans and a Patient with Glucose-Galactose Malabsorption
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چکیده
منابع مشابه
Renal and intestinal hexose transport in familial glucose-galactose malabsorption.
Glucose transport by jejunal mucosa in vitro and kidney in vivo was investigated in a 3 yr old patient with congenital glucose-galactose malabsorption, her family, and 16 normal volunteers. Glucose transport by normal human jejunal mucosa was concentrative, saturable, sodium and energy dependent, and exhibited competitive inhibition. Biopsy specimens from six normal controls and an asymptomatic...
متن کاملQuantitative Radioautography of Sugar Transport
A B S T R A C T Both galactose accumulation and phlorizin binding by columnar epithelial cells have been investigated in vitro with a recently developed technique for high-resolution, plastic-section radioautography which is particularly suited to small quantities of biopsy tissue. Grain density analysis of the radioautographs provides definitive support for the view that the cellular mechanism...
متن کاملA Case Report of Glucose-Galactose Malabsorption in Iranian Child
Introduction Glucose-Galactose Malabsorption (GGM) is an autosomal recessive and rare disorder of intestinal transport of glucose and sodium-glucose cotransporter type (SGLT1). Case Report Our patient is a 32-day-old boy who was examined for severe diarrhea and acidosis and was treated with GGMdiagnosis. A number of laboratory tests were performed on this patient as well as positive test for r...
متن کاملIntestinal fructose transport and malabsorption in humans.
Fructose is a hexose sugar that is being increasingly consumed in its monosaccharide form. Patients who exhibit fructose malabsorption can present with gastrointestinal symptoms that include chronic diarrhea and abdominal pain. However, with no clearly established gastrointestinal mechanism for fructose malabsorption, patient analysis by the proxy of a breath hydrogen test (BHT) is controversia...
متن کاملCongenital glucose galactose malabsorption.
Introduction Congenital glucose galactose malabsorption (CGGM) is a rare autosomal recessive disorder, which presents as a protracted diarrhoea in early neonatal life. It is due to a defect in sodium coupled transport of glucose and galac tose in the enterocyte (1). Diarrhoea in CGGM is osmotic, caused by accumulation of unabsorbed glucose and ga lactose in the intestine (2), which results in...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1972
ISSN: 0021-9738
DOI: 10.1172/jci106830